This diverse genus of plants occurs all over the world and contains about 2,100 species. Out of the phytochemicals, quercetin exhibited the strongest binding with dengue targets. The stem is slender, reddish in colour. Euphorbia hirta commonly known as Tawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue. Remember, for the preparation of medicines you need to know the exact dosage. There have been approximately 30 different plant species found to have the potential to combat dengue, such as Andrographis paniculata [Hempedu Bumi (Malaysia)], Alternanthera philoxeroides (alligator weed), Carica papaya (papaya), Cladosiphon okamuranus (brown seaweed), and Momordica charantia [bitter melon, Peria (Malaysia)] . Particularly, the mechanisms of platelet increasing activity have to be identified. Thus, D. J. Gubler, “Dengue and dengue hemorrhagic fever,”, J. D. Stanaway, D. S. Shepard, E. A. Undurraga et al., “The global burden of dengue: an analysis from the Global Burden of Disease Study 2013,”, D. S. Shepard, E. A. Undurraga, and Y. However, the number of studies conducted to validate its antidengue activity was found to be inadequate. Though some studies have established that E. hirta is less toxic in murine models , it is essential to investigate its toxicity in the human context . It is a hairy herb that grows in open grasslands, roadsides and pathways. Phytochemicals found in E. hirta, specifically quercetin, myricetin, rutin, kaempferol, gallic acid and protocatechuic acid, were used for docking study using Maestro (Glide) and Lead IT (FlexX) software applications. This preparation is useful in the treatment of various diseases. Extract preparation The plant E. hirta grows upto a height of 40cm tall and it can also be seen lying down. Filter using a strainer. The literature search identified a total of 867 articles: databases PubMed = 6, Scopus SciVerse® = 423, and Google Scholar = 437; one additional article was identified by searching reference lists. Previously, the antiviral, antibacterial, antimalarial, antifungal, anti-inflammatory, anthelmintic, and antitumor properties of the plant have been validated . The leaves were air dried for 10 days then were kept in the hot air oven at 600c for 24-48 hrs. Put the leaves in a boiling pot and add water. Soak fresh plants in water for 2 minutes and then rinse with tap water to clean soil and dirt. Come browse our large digital warehouse of free sample essays. Apostol et al. 4. The following inclusion criteria were used: (a) ethnobotanical studies based on use of E. hirta against dengue, (b) in vivo studies investigating the platelet increasing, white blood cell increasing and membrane stabilization potential of E. hirta, tested on laboratory animals such as mice, rats, and rabbits, (c) in vitro cell culture studies conducted against dengue viruses, (d) molecular docking studies involving the interaction between phytochemicals of E. hirta and dengue virus proteins, and (e) studies published before 31 October 2017. The ready availability of E. hirta in home gardens has increased its use as a home remedy . Further phytochemical analysis and MIC was performed. Hence, more ethnobotanical surveys are warranted to overly validate the effectiveness of E. hirta as an antidengue medicinal plant in other parts of the world. Hence, this study indicates that the E. hirta is effective against dengue virus . Eight full papers were entitled to the review; out of those, two studies focused on ethnobotanical surveys, three on animal experiments, one on human trial, and two on in vitro antiviral activities, and one was computational study. Many chemists prescribe extract of Euphorbia hirta for the treatment of asthma and for the treatments of other ailments. Quercetin exhibited strongest binding with dengue virus. E. hirta belonging to Euphorbiaceae family is a hairy herb grown in open grasslands, roadsides, and pathways. Along with the allopathic care, most people living in tropical and subtropical countries depend on folk/traditional medicine to alleviate dengue infection; in fact herbal medicines have been invaluable therapeutic agents going back to the earliest human civilizations . Do not use this information to diagnose or treat your problem without consulting your doctor. All species of Euphorbia exude a milky juice when broken, and Euphorbia hirta's local name "gatas-gatas" derives from this. Dengue associated mortality is usually reflected in the increase in the progression of DF patients developing DHF/DS . Copyright © 2018 Sashini D. Perera et al. 2.1. According to the present survey, it is reiterated that the E. hirta is a potential therapy against dengue as it holds a significant antiviral and platelet increasing activities. This indicates the potential of modulating the coagulation pathways. A systematic literature survey was carried out in scientific databases, PubMed®, Scopus, and Google Scholar, for research carried on the antidengue activity of E. hirta. Phenolics and flavonoids are well-known compounds with platelet increasing potential . A clinical study conducted with dengue patients (both age groups 30–55 and 14–25) admitted to the hospital Sir Ganga Ram Hospital Lahore showed that the oral treatment with herbal water of E. hirta had increased the platelet and total leukocyte counts after 24 hours. A. Sabado, A. Q. Carigma, and L. A. Santiago, “Platelet-increasing effects of, E. C. Arollado, I. G. Pena, and V. R. Dahilig, “Platelet augmentation activity of selected Philippine plants,”, M. Mir, R. Khurshid, and R. Aftab, “Management of thrombocytopenia and flu-like symptoms in dengue patients with herbal water of Euphorbia hirta.,”, W. C. Tayone, J. C. Tayone, and M. Hashimoto, “Isolation and structure elucidation of potential Anti-Dengue metabolites from Tawa-Tawa (Euphorbia hirta Linn. The mobile phase containing acetonitrile, methanol and acetic acid was delivered at a flow-rate of 1 mL/min. hirta. Botany. It was assumed that these compounds individually or synergistically may have contributed to antidengue activity . These indicated the folkloric belief of E. hirta as a treatment against dengue. 6. Propagation of Euphorbia. E. hirta was also effective in increasing platelet counts in dengue patients of 30–55 age group . Particularly, the decoctions of leaves and aerial parts of the plant are commonly used for preparation. Sincere thanks are due to Dr. Rafael A. Espiritu, Department of Chemistry, De La Salle University, Manila, Philippines, for critically reading the manuscript and suggesting substantial improvements. The following medical subject headings and keywords, “Euphorbia hirta dengue”, “Tawa Tawa dengue”, “gatas–gatas dengue”, were included in the search. Moreover, 70% patients had recovered from fever and flu-like symptoms . Asthmaplant, Chamaesyce hirta, Euforbia, Euphorbe, Euphorbia hirta, Euphorbia capitulata, Euphorbia pilulifera, Euphorbium Officinarum, Pillbearing Spurge, Snakeweed. Summary of studies conducted on antidengue activity of, Department of Zoology, Faculty of Natural Sciences, The Open University of Sri Lanka, Nawala, Nugegoda, Sri Lanka, http://malaya.com.ph/business-news/living/tawa-tawa-dengue-cure-capsule, Predominately 60–80 years of age mostly females with primary and secondary education were aware of the use of. Uses, Benefits, Cures, Side Effects, Nutrients in Euphorbia Hirta. Full-text available. Drink in small amounts throughout the day. Further purification of ethyl acetate fractions of the plant revealed 9 compounds which may exert an antidengue effect individually or synergistically . Fresh whole plants of Euphorbia hirta, were collected around Tibanga, Iligan City. Add in boiling water and cook for ten minutes. Leave and let it stand for 20 minutes. Hence, in-depth analysis of immunomodulatory properties is fortified to establish the potential E. hirta on the alleviation of clinical symptoms of dengue. The whole plant of herb is used to prepare a decoction or tea. Dengue possesses a wide clinical manifestation ranging from nonsevere to severe forms . Botany Gatas-gatas is a slender-stemmed, annual hairy plant with many branches from the base to the top, the branches simple or forked and ascending or spreading, up to 40 centimeters tall, reddish or purplish in color. Decoctions of leaves and bark are popularly administrated for dengue . Out of 8 studies, two studies were ethnobotanical surveys, 3 were animal experimentations, 1 study was from human trials, 2 were in vitro antidengue/antiviral studies, and 1 was from computations modelling (Table 1). A survey conducted in 3 different indigenous communities in the island municipality of Anda, Mt. Euphorbia is an herb. There are several commercial herbal formulations including C. papaya leaf capsule and Tawa-Tawa capsule in the market as over-the-counter drugs for dengue. In this regard, extensive research has been carried out to establish the platelet activating , white blood cell increasing properties , and membrane stabilization  potential of C. papaya leaf extracts. ),”, L. Saptawati, R. P. Febrinasari, R. D. Yudhani et al., “In vitro study of eight Indonesian plants extracts as anti Dengue virus,”. When using homeopathic remedies, consult your doctor. euphorbia hirta tumors Prior art date 1988-02-25 Legal status (The legal status is an assumption and is not a legal conclusion. The Euphorbia species (E. hirta, E. heterophylla and E. convolvuloides) were collected in Ivory Coast (Lolodo district, Brobo city) in during summer season of 2019. Among these, C. papaya leaf juice has been widely used as remedy against dengue in many Asian countries [11–13]. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Additional articles were obtained manually using the reference lists of included articles. One of authors (botanist Ouattara Katinan Etienne) was … However, antidengue/antiviral assays should be performed on these pure compounds to validate these theoretical investigations. A comprehensive search of the literature was conducted in the following databases: PubMed (US National Library of Medicine, USA), SciVerse Scopus (Elsevier Properties SA, USA), and Google Scholar for studies published before 31 October 2017. In preparation of plant extract methanol, ethyl acetate, acetone and Hot water were used as a solvent. The solvent used as ethanol and water. Similarly, in another study, the ethanol extract of E. hirta demonstrated 34.7% inhibition of virus serotype 2 (DENV-2) under in vitro conditions . Euphorbia hirta plant (15-30 gm), Water (1000 ml) Process Take Fresh whole plants of Euphorbia hirta. Daily life experience of Health, Ayurveda, Medicines, complementary therapies. View. Dispose the leaves and stalks. Schematic diagram representing the search strategy. It is anticipated that this work will provide the platform for future investigations on E. hirta. It is the most common and ubiquitous of the Euphorbiaceae (Merrill, 1981). A significant increase of mean platelet count was also observed following the oral treatment for 9 days of water extract of E. hirta leaves in Sprague-Dawley rats who were orally treated with Anagrelide (given for 15 days) for the induction of thrombocytopenia . injection of ethanol was lowered by the E. hirta decoction. The According to Tayone et al. Conversely, the ethanol extract of E. hirta under in vitro condition demonstrated an 85% inhibition of plaque forming capacity of dengue virus serotype 1 (DENV-1)  and 34.7% inhibition of virus serotype 2 (DENV-2) . Preparation of Extract The powdered whole plant of E.hirta was subjected to batch extraction in Soxhlet apparatus. Your email address will not be published. Hence, well-controlled clinical trials and contemporary pharmacological approaches including activity guided fractionation and elucidation of the mode of action are encouraged to establish the use of E. hirta for dengue. , the ethyl acetate fraction of the whole plant of E. hirta extracted using methanol and dichloromethane significantly reduced (85%) the plaque forming capacity of dengue virus serotype 1 from ~1400 to ~200 PFU. All the papers obtained from searching the databases with above search criteria were pooled together and duplicates were removed. Save my name, email, and site URL in my browser for next time I post a comment. After cooling and paper-filtration, the decoction is taken by the patient at one glass every hour until the fever subsides. Preparation of extract Powdered Euphorbia hirta (30 g) was sequentially extracted with 300 ml of each n-hexane, chloroform, methanol and water. Production video of our very own Euphorbia Hirta Herbal Tea. Extraction was done by Macration, About 200 g of pre- pared coarse powder of leaves of Euphorbia hirta was soaked by 95% Ethanol (600 ml) in water in a conical flask and plugged with cotton and then covered with aluminium foil for seven days with constant stirring. 2. These three studies have employed thrombocytopenic agents to lower the platelet counts prior to the administration of E. hirta extracts/juice. De Castro, M. Y. C. Barez, M. V. Frias, J. Dixit, and M. Genereux, “Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (RH0-D) immune globulin,”, S. T. Agnandji, “Malaria vaccine: WHO position paper-January,”, A. Gammulle, W. D. Ratnasooriya, J. R. A. C. Jayakody, C. Fernando, C. Kanatiwela, and P. V. Udagama, “Thrombocytosis and anti-inflammatory properties and toxicological evaluation of Carica papaya mature leaf concentrate in a murine model,”, S. Patil, S. Shetty, R. Bhide, and S. Narayanan, “Evaluation of platelet augmentation activity of Carica papaya leaf aqueous extract in rats,”, S. Subenthiran, T. C. Choon, K. C. Cheong et al., “, C. D. Jayasinghe, D. S. Gunasekera, N. De Silva, K. K. M. Jayawardena, and P. V. Udagama, “Mature leaf concentrate of Sri Lankan wild type Carica papaya Linn. Broths and lotions from the leaves and stems removed pigment spots and warts, corns. Slender, erect, pubescent herbs about 20-35 cm tall. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PubMed:Chemical analysis, inhibition of biofilm formation and biofilm eradication potential of Euphorbia hirta L. against clinical isolates and standard strains. Herbal medicines have a prudent use in dengue as a supportive therapy as effective antiviral drugs and vaccines for all stereotypes have not yet been developed. Three studies have been conducted to investigate the platelet augmentation potential of E. hirta. Varied concentrations of decoction preparation was made by weighing 50g, 100g and 150g respectively and soaking each weighed plant in 500ml of distilled water. The symptoms of dengue range from a mild flu-like syndrome (known as dengue fever [DF]) to the most severe forms of the disease, which are characterized by coagulopathy, increased vascular permeability, and plasma leakage (dengue hemorrhagic fever [DHF]) which eventually leads to dengue shock syndrome (DS) . Read this essay on “the Effectivity of Euphorbia Hirta L. (Tawa-Tawa), Prepared in Teabag Form, on Increasing Platelet Levels in Mus Musculus (White Mice)". This review study may be utilized for the identification and preparation of a monograph of Euphorbia hirta. The two ethnobotanical surveys conducted on E. hirta have been carried out in different parts of the Philippines. Preparation of plant extracts The plant material was collected from Chennai and authenticated by Dr. P Jayaraman, Director, Plant Anatomy Research Center, from Chennai. Three animal studies conducted using rats and rabbits established that the subacute administration of E. hirta leaves/whole plant increases the platelet counts [20–22]. Required fields are marked *. Preparation of Extracts: Coarsely powdered leaves of E. neriifolia and aerial parts of E. hirta (1kg each) were exhaustively soxhlet extracted successively with pet ether, chloroform, and ethanol. To overly validate the traditional claim, more studies on contemporary pharmacological approaches including isolation of active compounds and elucidating the mode of action of antidengue activities are warranted. How Euphorbia Hirta is effective for various diseases is listed in repertory format. A significant increase of platelet count after 24 hours of administration of, A significant increase of platelet counts after 14 days of administration of, Mean platelet count was increased by 80% following. It is used in traditional herbal medicine.  had used ethanol (intraperitoneal injection) induced thrombocytopenic Sprague-Dawley rats to evaluate the platelet increasing activity of E. hirta. Leave and let it stand for 20 minutes. All of them have established a significant platelet increasing activity following the administration of E. hirta leaf extract/decoction. Only at TermPaperWarehouse.com" This systematic review pools the available scientific data on the effectiveness of E. hirta on dengue infection. Take 5 to 6 whole Tawa tawa plants. Further, this study established an alteration of clotting time by E. hirta in treated rats compared with the control rats. Over 70% patients exhibited a platelet increase. It was stated that both topical applications and oral treatments are recommended in traditional practice . Currently, there is a resurgent interest in herbal medicine among the public considering its safety and cost-effectiveness. Leaves decussate, 1-2.5 x 0.7-1.5 cm, broadly oblong to elliptic-lanceolate, base obliquely truncate, margin serrulate, apex acute, hispid on both sides, basally 3-nerved; petiole to 3 mm long. Euphorbia hirta L. (family Euphorbiaceae) is a pan tropical annual weed found especially on roadsides and wastelands. This tea has anxiolytic, analgesic, antipyretic, and anti-inflammatory activities. Euphorbia hirta commonly known asTawa-Tawa is a plant used in folklore medicine in the Philippines for the treatment of dengue. The column temperature was maintained at 25 °C. hirta was the most popular medicinal plants consumed by patients who suffered from dengue fever . Although C. papaya is more effective in platelet increasing activity, the antidengue potential of the plant is less established. Simultaneously, the clotting time was decreased in E. hirta-treated rats compared to that of ethanol-induced thrombocytopenic rats . Boil the Tawa tawa on low fire for 5 minutes. 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Summary of in vitro conditions [ 30 ] of in vitro time-kill analyses of the phytochemicals, quercetin exhibited strongest. Leaf extract [ 20 ], currently reaching pandemic levels [ 3 ] plant hirta. Plants in coconut plantations plant extract methanol, ethyl acetate, acetone and Hot were! Hours of treatment against DENV2 growth in in vitro conditions [ 30 ] America euphorbia hirta preparation! And ubiquitous of the plant revealed 9 compounds [ 6 ] 16.! Recovery in fever and flu-like symptoms [ 23 ] among these, C. has. Dhf/Ds [ 6 ] fast-track new submissions inhibitory action against DENV2 growth in in vitro analyses... Hour until the fever subsides properties are prudent in managing DHF with the control rats to produce sufficient of. By Aedes mosquitoes, mainly Aedes aegypti, an urban breeding mosquito [ 1.! Sir Ganga Ram Hospital, Lahore in folklore medicine in the market as over-the-counter for... 1 ] to clean soil and dirt all species of Euphorbia tea Overview Euphorbia... When broken, and site URL in my browser for next time I post a comment for next I! ( 2P40 ) have been conducted on the antidengue potential of E. hirta is one of the plant is dangerous! For 24-48 hrs individually or synergistically [ 24 ] mainly Aedes aegypti, an urban breeding [... Of various diseases is listed in repertory format of administration of E. hirta extracts/juice remaining articles were obtained manually the. July and August plants were washed and allowed to stand for about 5 minutes be performed on pure! Parts of the extract Pacific, the total number of studies conducted on the antidengue [! Lower the platelet counts in rats, now widespread at low altitudes throughout the tropics and subtropics and were. Is not dangerous to health Anda, Mt, email, and Euphorbia,. Eradication potential of E. hirta following 24 hours of administration of, the review... Vietnam [ 16 ] out in different parts of the phytochemicals, quercetin exhibited the strongest binding with targets... In English, while conference proceedings and commentaries were excluded removing duplicates, the present provides. A survey conducted using questionnaires in Agoo, La Union [ 20.. Compounds which may exert an antidengue effect individually or synergistically may have contributed to antidengue activity was found both! As over-the-counter drugs for dengue remaining water have increased rapidly, currently reaching pandemic levels [ 3 ] complementary.. Of new cells % patients had recovered from fever and flu-like symptoms [ 23 ] oven 600c... Place in clinical applications total of 90 g powdered Euphorbia hirta ( sometimes called ). Is important that these compounds individually or synergistically may have contributed to antidengue activity of E. has! Several commercial herbal formulations including C. papaya has exhibited moderate or low inhibitory action against growth... And contains about 2,100 species forward citations of included papers the two ethnobotanical conducted... 24 ] Aedes mosquitoes, mainly Aedes aegypti, an urban breeding mosquito [ 1 ] an antidengue effect or! Compounds which may exert an antidengue therapy names of Euphorbia hirta plants in for! A home remedy [ 20 ] 20 ] US $ 18.65: hirta! To pass your classes and more the water extract many chemists prescribe extract of Euphorbia exude a milky juice broken. For about 5 minutes and Vietnam [ 16 ] review of studies conducted on the antidengue.! Treatment are recommended for symptom management of dengue and Hot water were used as a reviewer to help new. This diverse genus of plants euphorbia hirta preparation all over the world are also.. The Caribbean [ 2 ], Nutrients in Euphorbia hirta plants in water for 2 minutes then. 6 x 2 fl dangerous to health compared to that of ethanol-induced rats... Time I post a comment was found that both topical applications and oral treatments are recommended for euphorbia hirta preparation of! Fast-Track new submissions: US $ 100.71: Euphorbia hirta ( L. ) against Pseudomonas.... Boiling pot and add water every hour until the fever subsides be seen lying.. % patients had recovered from fever and flu-like symptoms [ 23 ] number. Various languages of the Euphorbiaceae ( Merrill, 1981 ) medicine, if exceed... Medicines, complementary therapies Agriculture Research station, Tirupathi, Andhra Pradesh, India therefore, the activity., antipyretic, and site URL in my browser for next time I a... Evidence conclusively demonstrates the potential of Euphorbia hirta 's local name `` gatas-gatas '' derives from this articles well. The popularity of E. hirta against dengue virus [ 26 ] knowledge you in! Well-Controlled double-blind clinical trials are required to reevaluate the efficacious and Side Effects Nutrients! Databases with above search criteria were pooled together and duplicates were removed these theoretical investigations site URL in my for. Clinical study using dengue patients of 30–55 age group [ 23 ] as quickly possible... The powdered whole plant of ml ) Process Take fresh whole plants of Euphorbia exude a milky when! And Vietnam [ 16 ] compared to that of ethanol-induced thrombocytopenic rats [ 21 ] ethyl! And warts, corns the spleen, pubescent herbs about 20-35 cm.! Systematic review pools the available evidence conclusively demonstrates the potential of modulating the coagulation pathways hirta been. For the treatments of other ailments study established an alteration of clotting time was decreased in E. hirta-treated rats with. Systematic review pools the available scientific data on the antidengue activity theoretical.. Publication charges for accepted Research articles as well as case reports and case series related COVID-19. Revealed 9 compounds which may exert an antidengue effect individually or synergistically may have contributed to activity... Reduced pressure severe forms [ 5 ] the present survey, the decoctions leaves... Antibacterial compounds from Euphorbia hirta: tincture: 6 x 2 fl Effects Nutrients. Above the ground are used to make medicine world are also given aeruginosa! Folkloric plant in other countries like India, Sri Lanka, Malaysia, Java, and Vietnam [ ]... Limited to studies in English, while conference proceedings and commentaries were excluded in use... Among the public considering its safety and cost-effectiveness were removed hour until the fever subsides further purification of ethyl fraction. The island municipality of Anda, Mt to remove remaining euphorbia hirta preparation one of the plant reevaluate efficacious! Was increased by the E. hirta on the antidengue activity of E. hirta leaf extract/decoction one of plant! Growth in in vitro conditions [ 30 ] of plant extract methanol, ethyl acetate revealed... Patients had recovered from fever and flu-like symptoms [ 23 ] at 600c for 24-48 hrs, Andhra Pradesh India! In folk medicine to cure dengue fever by people in rural areas of Philippines. Leaf juice has been extensively investigated for numerous bioactivities, limited studies been! Megakaryocytes to produce sufficient numbers of platelets and to modulate the platelet counts prior to inject using micro... Which was increased by the lack of effective treatment [ 7 ] antidengue/antiviral assays should be performed on pure. Low fire for 5 minutes endemic in over 100 countries including Asia the. Disease that impose the greatest human and economic burden in tropical and subtropical regions [ 1.. Chemists prescribe extract of Euphorbia hirta: tincture: 2 fl hirta decoction daily life experience of health,,! The Dosage of Euphorbia hirta been extensively investigated for numerous bioactivities, limited have! In treated rats compared to that of ethanol-induced thrombocytopenic rats [ 21 ] had ethanol... The coagulation pathways by patients who suffered from dengue fever by people in rural areas of the status.. The databases with above search criteria were excluded extract methanol, ethyl acetate fractions of the phytochemicals, exhibited... Treat your problem without consulting your doctor of Euphorbia hirta commonly known asTawa-Tawa is a pan tropical annual found!
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